Crafting novel synthetic methodologies at the intersection of ylide chemistry, bioactive scaffold design, and drug discovery — from NIPER Mohali to the world.
I am a Doctoral Researcher in Medicinal Chemistry at the National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, under the guidance of Prof. Sankar K. Guchhait, FRSC. My doctoral research focuses on developing novel synthetic methodologies using ylide chemistry to construct bioactive heterocyclic scaffolds for drug discovery.
My Ph.D. work established multifunctional ylides as versatile masked synthons, enabling highly efficient and selective construction of complex molecular architectures. A key discovery — the dual ambiphilic reactivity of nitrile-stabilized ylides — has significantly broadened the synthetic utility of this reagent class.
Prior to my Ph.D., I completed my M.S. at NIPER Ahmedabad where I contributed to green chemistry research including nickel-catalyzed aqueous-phase synthesis and HDAC inhibitor design — yielding 5 co-authored publications across ACS, Green Chemistry, and Eur. J. Med. Chem.
Developing new synthetic strategies using sulfoxonium, quaternary ammonium, and nitrile-stabilized ylides for complex molecule construction via (4+1) annulation and cyclopropanation pathways.
Synthesizing diverse heterocyclic frameworks — benzofurans, oxindoles, spirocycles, α-carbolines — as privileged scaffolds with drug-relevant biological profiles.
Applying scaffold hopping and SAR studies to identify anticancer, CNS, and anti-infective chemotypes. Contributor to major drug discovery reviews in leading journals.
Expertise in microwave-assisted synthesis, aqueous-phase Ni-catalysis, and atom-economical transformations. Co-inventor of a granted patent for green pharmaceutical synthesis.
This doctoral work explores multifunctional ylides as versatile masked synthons for efficient construction of diverse bioactive heterocyclic scaffolds. Established ylide-mediated annulation and cyclization strategies providing streamlined access to benzofurans, 2,3-dihydrobenzofurans, spiro-cyanocyclopropane-oxindoles, and 2-amino-α-carbolines. Discovered that nitrile-stabilized ylides act as dual ambiphiles functioning via both Ar–C–CN and Ar–C–C–NH₂ pathways, significantly expanding synthetic utility for drug-relevant scaffold construction.
A sustainable, atom-economical nickel-catalyzed aqueous-phase process for pharmaceutical synthesis. Demonstrates industry-ready green chemistry principles with direct scale-up application.
Diastereoselective ylide-based synthesis of spiro-indolyl compounds with significant pharmaceutical relevance — directly emerging from first-author Ph.D. research.
RABMC-2025 Symposium · IIT Ropar, Punjab, India
ChemSpirit-2025 International Conference · IIT Hyderabad, India
NIPER-PHARMACON 2022 International Conference · NIPER Mohali, India
CRSI-NSC 2022 Symposium · IISER Mohali, Punjab, India
I welcome collaborations, discussions, and opportunities in synthetic chemistry, medicinal chemistry, and drug discovery research from institutions worldwide.